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Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation
Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed by D...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3761600/ https://ncbi.nlm.nih.gov/pubmed/23940330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306752110 |
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