Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed by D...

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Main Authors: Galick, Heather A., Kathe, Scott, Liu, Minmin, Robey-Bond, Susan, Kidane, Dawit, Wallace, Susan S., Sweasy, Joann B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761600/
https://ncbi.nlm.nih.gov/pubmed/23940330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306752110
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