The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium

In the present study, we compared the cardioprotective effects of TRV120023, a novel angiotensin II (ANG II) type 1 receptor (AT(1)R) ligand, which blocks G protein coupling but stimulates β-arrestin signaling, against treatment with losartan, a conventional AT(1)R blocker in the treatment of cardia...

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Detaylı Bibliyografya
Asıl Yazarlar: Monasky, Michelle M., Taglieri, Domenico M., Henze, Marcus, Warren, Chad M., Utter, Megan S., Soergel, David G., Violin, Jonathan D., Solaro, R. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2013
Konular:
Cardiovascular Neurohormonal Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761345/
https://ncbi.nlm.nih.gov/pubmed/23873795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00327.2013
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