The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium

In the present study, we compared the cardioprotective effects of TRV120023, a novel angiotensin II (ANG II) type 1 receptor (AT(1)R) ligand, which blocks G protein coupling but stimulates β-arrestin signaling, against treatment with losartan, a conventional AT(1)R blocker in the treatment of cardia...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Monasky, Michelle M., Taglieri, Domenico M., Henze, Marcus, Warren, Chad M., Utter, Megan S., Soergel, David G., Violin, Jonathan D., Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Cardiovascular Neurohormonal Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761345/
https://ncbi.nlm.nih.gov/pubmed/23873795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00327.2013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados