Therapeutic Effects of Anti-CD115 Monoclonal Antibody in Mouse Cancer Models through Dual Inhibition of Tumor-Associated Macrophages and Osteoclasts

Tumor progression is promoted by Tumor-Associated Macrophages (TAMs) and metastasis-induced bone destruction by osteoclasts. Both myeloid cell types depend on the CD115-CSF-1 pathway for their differentiation and function. We used 3 different mouse cancer models to study the effects of targeting can...

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Detalhes bibliográficos
Main Authors: Fend, Laetitia, Accart, Nathalie, Kintz, Jacqueline, Cochin, Sandrine, Reymann, Carine, Le Pogam, Fabrice, Marchand, Jean-Baptiste, Menguy, Thierry, Slos, Philippe, Rooke, Ronald, Fournel, Sylvie, Bonnefoy, Jean-Yves, Préville, Xavier, Haegel, Hélène
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760897/
https://ncbi.nlm.nih.gov/pubmed/24019914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073310
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