A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells

Cancer progression has been associated with the presence of tumor-associated M2-macrophages (M2-TAMs) able to inhibit anti-tumor immune responses. It is also often associated with metastasis-induced bone destruction mediated by osteoclasts. Both cell types are controlled by the CD115 (CSF-1R)/colony...

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Main Authors: Haegel, Hélène, Thioudellet, Christine, Hallet, Rémy, Geist, Michel, Menguy, Thierry, Le Pogam, Fabrice, Marchand, Jean-Baptiste, Toh, Myew-Ling, Duong, Vanessa, Calcei, Alexandre, Settelen, Nathalie, Preville, Xavier, Hennequi, Marie, Grellier, Benoit, Ancian, Philippe, Rissanen, Jukka, Clayette, Pascal, Guillen, Christine, Rooke, Ronald, Bonnefoy, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851226/
https://ncbi.nlm.nih.gov/pubmed/23924795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25743
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