JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

Neurons are highly polarized cells that often project axons a considerable distance. To respond to axonal damage, neurons must transmit a retrograde signal to the nucleus to enable a transcriptional stress response. Here we describe a mechanism by which this signal is propagated through injury-induc...

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Detalhes bibliográficos
Main Authors: Huntwork-Rodriguez, Sarah, Wang, Bei, Watkins, Trent, Ghosh, Arundhati Sengupta, Pozniak, Christine D., Bustos, Daisy, Newton, Kim, Kirkpatrick, Donald S., Lewcock, Joseph W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760612/
https://ncbi.nlm.nih.gov/pubmed/23979718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201303066
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