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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. Here we show that the mixed-lineage dual leucine zipper kinase (DLK) is an essential upstream mediator of both of these divergent outcomes in the same cell...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593899/ https://ncbi.nlm.nih.gov/pubmed/23431164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211074110 |
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