Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show that PERK signaling is a component of the...

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Bibliographic Details
Published in:eLife
Main Authors: Larhammar, Martin, Huntwork-Rodriguez, Sarah, Jiang, Zhiyu, Solanoy, Hilda, Sengupta Ghosh, Arundhati, Wang, Bei, Kaminker, Joshua S, Huang, Kevin, Eastham-Anderson, Jeffrey, Siu, Michael, Modrusan, Zora, Farley, Madeline M, Tessier-Lavigne, Marc, Lewcock, Joseph W, Watkins, Trent A
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404924/
https://ncbi.nlm.nih.gov/pubmed/28440222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20725
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