Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

Using a microchannel assay, we demonstrate that cells adopt distinct signaling strategies to modulate cell migration in different physical microenvironments. We studied α4β1 integrin–mediated signaling, which regulates cell migration pertinent to embryonic development, leukocyte trafficking, and mel...

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Bibliographic Details
Main Authors: Hung, Wei-Chien, Chen, Shih-Hsun, Paul, Colin D., Stroka, Kimberly M., Lo, Ying-Chun, Yang, Joy T., Konstantopoulos, Konstantinos
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760608/
https://ncbi.nlm.nih.gov/pubmed/23979717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302132
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