Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control

Activation of the DNA replication checkpoint by the ATR kinase requires protein interactions mediated by the ATR activating protein, TopBP1. Accumulation of TopBP1 at stalled replication forks requires the interaction of TopBP1 BRCT5 with the phosphorylated SDT repeats of the adaptor protein MDC1. H...

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Bibliografski detalji
Glavni autori: Leung, Charles Chung Yun, Sun, Luxin, Gong, Zihua, Burkat, Michael, Edwards, Ross, Assmus, Mark, Chen, Junjie, Glover, J.N. Mark
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760280/
https://ncbi.nlm.nih.gov/pubmed/23891287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.015
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