Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control

Activation of the DNA replication checkpoint by the ATR kinase requires protein interactions mediated by the ATR activating protein, TopBP1. Accumulation of TopBP1 at stalled replication forks requires the interaction of TopBP1 BRCT5 with the phosphorylated SDT repeats of the adaptor protein MDC1. H...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leung, Charles Chung Yun, Sun, Luxin, Gong, Zihua, Burkat, Michael, Edwards, Ross, Assmus, Mark, Chen, Junjie, Glover, J.N. Mark
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760280/
https://ncbi.nlm.nih.gov/pubmed/23891287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.015
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