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TopBP1 Controls BLM Protein Level to Maintain Genome Stability
Human TopBP1 is a key mediator protein involved in DNA replication checkpoint control. In this study, we report a specific interaction between TopBP1 and Bloom syndrome helicase (BLM) that is phosphorylation and cell cycle dependent. Interestingly, TopBP1 depletion led to decreased BLM protein level...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880544/ https://ncbi.nlm.nih.gov/pubmed/24239288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.012 |
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