Active-site models for complexes of quinolinate synthase with substrates and intermediates

Quinolinate synthase (QS) catalyzes the condensation of iminoaspartate and dihydroxyacetone phosphate to form quinolinate, the universal precursor for the de novo biosynthesis of nicotinamide adenine dinucleotide. QS has been difficult to characterize owing either to instability or lack of activity...

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Bibliographische Detailangaben
Hauptverfasser: Soriano, Erika V., Zhang, Yang, Colabroy, Keri L., Sanders, Jennie M., Settembre, Ethan C., Dorrestein, Pieter C., Begley, Tadhg P., Ealick, Steven E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2013
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760129/
https://ncbi.nlm.nih.gov/pubmed/23999292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744491301247X
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