Active-site models for complexes of quinolinate synthase with substrates and intermediates

Quinolinate synthase (QS) catalyzes the condensation of iminoaspartate and dihydroxyacetone phosphate to form quinolinate, the universal precursor for the de novo biosynthesis of nicotinamide adenine dinucleotide. QS has been difficult to characterize owing either to instability or lack of activity...

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Bibliographic Details
Main Authors: Soriano, Erika V., Zhang, Yang, Colabroy, Keri L., Sanders, Jennie M., Settembre, Ethan C., Dorrestein, Pieter C., Begley, Tadhg P., Ealick, Steven E.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2013
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760129/
https://ncbi.nlm.nih.gov/pubmed/23999292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744491301247X
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