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Active-site models for complexes of quinolinate synthase with substrates and intermediates

Quinolinate synthase (QS) catalyzes the condensation of iminoaspartate and dihydroxyacetone phosphate to form quinolinate, the universal precursor for the de novo biosynthesis of nicotinamide adenine dinucleotide. QS has been difficult to characterize owing either to instability or lack of activity...

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Detalhes bibliográficos
Main Authors: Soriano, Erika V., Zhang, Yang, Colabroy, Keri L., Sanders, Jennie M., Settembre, Ethan C., Dorrestein, Pieter C., Begley, Tadhg P., Ealick, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760129/
https://ncbi.nlm.nih.gov/pubmed/23999292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744491301247X
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