Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in t...

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Bibliographische Detailangaben
Hauptverfasser: Zemek, Filip, Zdarova, Jana Karasova, Sepsova, Vendula, Kuca, Kamil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Diversity Preservation International (MDPI) 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759900/
https://ncbi.nlm.nih.gov/pubmed/23917882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140816076
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