piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Transgenic expression of just four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state(1-4). The resulting induced pluripotent stem (iPS) cells resemble ES cells in their properties and potential to differentiate into a spectrum...

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Hlavní autoři: Woltjen, Knut, Michael, Iacovos P., Mohseni, Paria, Desai, Ridham, Mileikovsky, Maria, Hämäläinen, Riikka, Cowling, Rebecca, Wang, Wei, Liu, Pentao, Gertsenstein, Marina, Kaji, Keisuke, Sung, Hoon-Ki, Nagy, Andras
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758996/
https://ncbi.nlm.nih.gov/pubmed/19252478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07863
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