Mining Exomic Sequencing Data to Identify Mutated Antigens Recognized by Adoptively Transferred Tumor-reactive T cells

Significant tumor regressions have been observed in up to 70% of patients receiving adoptively transferred autologous melanoma-reactive tumor infiltrating lymphocytes (TIL) (1,2), and in pilot trials, 40% of treated patients experienced complete regressions of all measurable lesions for at least fiv...

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Hauptverfasser: Robbins, Paul F., Lu, Yong-Chen, El-Gamil, Mona, Li, Yong F., Gross, Colin, Gartner, Jared, Lin, Jimmy C., Teer, Jamie K., Cliften, Paul, Tycksen, Eric, Samuels, Yardena, Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757932/
https://ncbi.nlm.nih.gov/pubmed/23644516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3161
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