DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT

The consequences of DNA damage generation in mammalian somatic stem cells, including neural stem cells (NSCs), are poorly understood despite their potential relevance for tissue homeostasis. Here, we show that, following ionizing radiation-induced DNA damage, NSCs enter irreversible proliferative ar...

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Autores principales: Schneider, Leonid, Pellegatta, Serena, Favaro, Rebecca, Pisati, Federica, Roncaglia, Paola, Testa, Giuseppe, Nicolis, Silvia K., Finocchiaro, Gaetano, d’Adda di Fagagna, Fabrizio
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757751/
https://ncbi.nlm.nih.gov/pubmed/24052948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.06.004
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