DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT

The consequences of DNA damage generation in mammalian somatic stem cells, including neural stem cells (NSCs), are poorly understood despite their potential relevance for tissue homeostasis. Here, we show that, following ionizing radiation-induced DNA damage, NSCs enter irreversible proliferative ar...

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Autori principali: Schneider, Leonid, Pellegatta, Serena, Favaro, Rebecca, Pisati, Federica, Roncaglia, Paola, Testa, Giuseppe, Nicolis, Silvia K., Finocchiaro, Gaetano, d’Adda di Fagagna, Fabrizio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757751/
https://ncbi.nlm.nih.gov/pubmed/24052948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.06.004
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