Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

Hyperphosphorylation of microtubule-associated protein tau is thought to contribute to Alzheimer’s disease (AD) pathogenesis. We previously showed that DNA damage-activated cell cycle checkpoint kinases Chk1 and Chk2 phosphorylate tau at an AD-related site and enhance tau toxicity, suggesting potent...

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Hlavní autoři: Mendoza, Jhoana, Sekiya, Michiko, Taniguchi, Taizo, Iijima, Koichi M., Wang, Rong, Ando, Kanae
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757556/
https://ncbi.nlm.nih.gov/pubmed/23550703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr400008f
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