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Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

Hyperphosphorylation of microtubule-associated protein tau is thought to contribute to Alzheimer’s disease (AD) pathogenesis. We previously showed that DNA damage-activated cell cycle checkpoint kinases Chk1 and Chk2 phosphorylate tau at an AD-related site and enhance tau toxicity, suggesting potent...

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Autors principals: Mendoza, Jhoana, Sekiya, Michiko, Taniguchi, Taizo, Iijima, Koichi M., Wang, Rong, Ando, Kanae
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757556/
https://ncbi.nlm.nih.gov/pubmed/23550703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr400008f
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