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Generation of high-performance binding proteins for peptide motifs by affinity clamping

We describe concepts and methodologies for generating “Affinity Clamps”, a new class of recombinant binding proteins that achieve high affinity and high specificity toward short peptide motifs of biological importance, which is a major challenge in protein engineering. The Affinity Clamping concept...

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書目詳細資料
Main Authors: Koide, Shohei, Huang, Jin
格式: Artigo
語言:Inglês
出版: 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757518/
https://ncbi.nlm.nih.gov/pubmed/23422435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-394292-0.00013-8
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