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Generation of high-performance binding proteins for peptide motifs by affinity clamping
We describe concepts and methodologies for generating “Affinity Clamps”, a new class of recombinant binding proteins that achieve high affinity and high specificity toward short peptide motifs of biological importance, which is a major challenge in protein engineering. The Affinity Clamping concept...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757518/ https://ncbi.nlm.nih.gov/pubmed/23422435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-394292-0.00013-8 |
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