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pRb controls Estrogen Receptor alpha protein stability and activity

A cross talk between the Estrogen Receptor (ESR1) and the Retinoblastoma (pRb) pathway has been demonstrated to influence the therapeutic response of breast cancer patients but the full mechanism remains poorly understood. Here we show that the N-terminal domain of pRb interacts with the CD domain o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Caligiuri, Isabella, Toffoli, Giuseppe, Giordano, Antonio, Rizzolio, Flavio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757244/
https://ncbi.nlm.nih.gov/pubmed/23900261
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