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Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

Notch signaling makes critical contributions to cell fate determination in all metazoan organisms, yet remarkably little is known about the binding affinity of the four mammalian Notch receptors for their three Delta-like and two Jagged family ligands. Here, we utilized signaling assays and biochemi...

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Hlavní autoři: Andrawes, Marie Blanke, Xu, Xiang, Liu, Hong, Ficarro, Scott B., Marto, Jarrod A., Aster, Jon C., Blacklow, Stephen C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757209/
https://ncbi.nlm.nih.gov/pubmed/23839946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.454850
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