Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5

Hypoxia-inducible factor 1α (HIF-1α) and p53 are pivotal regulators of tumor growth. Lysophosphatidic acid (LPA) is a lipid mediator that functions as a mitogen by acting through LPA receptors. We have shown previously that LPA stimulates HIF-1α expression in colon cancer cells. To determine the mec...

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Détails bibliographiques
Auteurs principaux: Lee, Sei-Jung, No, Yi Ran, Dang, Duyen T., Dang, Long H., Yang, Vincent W., Shim, Hyunsuk, Yun, C. Chris
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757187/
https://ncbi.nlm.nih.gov/pubmed/23880760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489708
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