Kruppel-like Factor 2 Inhibits Hypoxia-inducible Factor 1α Expression and Function in the Endothelium

Hypoxia-inducible factor 1 (HIF-1) is a central regulator of the hypoxic response in many cell types. In endothelial cells, HIF-1 induces the expression of key proangiogenic factors to promote angiogenesis. Recent studies have identified Kruppel-like factor 2 (KLF2) as a potent inhibitor of angiogen...

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Bibliographic Details
Main Authors: Kawanami, Daiji, Mahabeleshwar, Ganapati H., Lin, Zhiyong, Atkins, G. Brandon, Hamik, Anne, Haldar, Saptarsi M., Maemura, Koji, LaManna, Joseph C., Jain, Mukesh K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742816/
https://ncbi.nlm.nih.gov/pubmed/19491109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025346
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