Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and fungal infections. Despite a...

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Main Authors: Lang, Philipp A., Shaabani, Namir, Borkens, Stephanie, Honke, Nadine, Scheu, Stefanie, Booth, Sarah, Brenner, Dirk, Meryk, Andreas, Barthuber, Carmen, Recher, Mike, Mak, Tak W., Ohashi, Pamela S., Häussinger, Dieter, Griffiths, Gillian M., Thrasher, Adrian J., Bouma, Gerben, Lang, Karl S.
Formato: Artigo
Idioma:Inglês
Publicado: Mosby 2013
Assuntos:
Immune Deficiencies, Infection, and Systemic Immune Disorders
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757164/
https://ncbi.nlm.nih.gov/pubmed/23141740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.08.050
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