Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and fungal infections. Despite a...

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Bibliographische Detailangaben
Hauptverfasser: Lang, Philipp A., Shaabani, Namir, Borkens, Stephanie, Honke, Nadine, Scheu, Stefanie, Booth, Sarah, Brenner, Dirk, Meryk, Andreas, Barthuber, Carmen, Recher, Mike, Mak, Tak W., Ohashi, Pamela S., Häussinger, Dieter, Griffiths, Gillian M., Thrasher, Adrian J., Bouma, Gerben, Lang, Karl S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2013
Schlagworte:
Immune Deficiencies, Infection, and Systemic Immune Disorders
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757164/
https://ncbi.nlm.nih.gov/pubmed/23141740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.08.050
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