Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase

Nanopore technologies are being developed for fast and direct sequencing of single DNA molecules through detection of ionic current modulations as DNA passes through a pore’s constriction(1,2). Here we demonstrate the ability to resolve changes in current that correspond to a known DNA sequence by c...

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Main Authors: Manrao, Elizabeth A, Derrington, Ian M, Laszlo, Andrew H, Langford, Kyle W, Hopper, Matthew K, Gillgren, Nathaniel, Pavlenok, Mikhail, Niederweis, Michael, Gundlach, Jens H
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757088/
https://ncbi.nlm.nih.gov/pubmed/22446694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2171
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