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Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase
Nanopore technologies are being developed for fast and direct sequencing of single DNA molecules through detection of ionic current modulations as DNA passes through a pore’s constriction(1,2). Here we demonstrate the ability to resolve changes in current that correspond to a known DNA sequence by c...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757088/ https://ncbi.nlm.nih.gov/pubmed/22446694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2171 |
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