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Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA

Precise and efficient mapping of epigenetic markers on DNA may become an important clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in gene expression and are biomarkers for diseases such as cancer. Here, we use the engineered biological protein pore Myc...

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Main Authors: Laszlo, Andrew H., Derrington, Ian M., Brinkerhoff, Henry, Langford, Kyle W., Nova, Ian C., Samson, Jenny Mae, Bartlett, Joshua J., Pavlenok, Mikhail, Gundlach, Jens H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839702/
https://ncbi.nlm.nih.gov/pubmed/24167255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310240110
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