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Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA

Precise and efficient mapping of epigenetic markers on DNA may become an important clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in gene expression and are biomarkers for diseases such as cancer. Here, we use the engineered biological protein pore Myc...

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Detalhes bibliográficos
Main Authors: Laszlo, Andrew H., Derrington, Ian M., Brinkerhoff, Henry, Langford, Kyle W., Nova, Ian C., Samson, Jenny Mae, Bartlett, Joshua J., Pavlenok, Mikhail, Gundlach, Jens H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839702/
https://ncbi.nlm.nih.gov/pubmed/24167255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310240110
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