Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA

Precise and efficient mapping of epigenetic markers on DNA may become an important clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in gene expression and are biomarkers for diseases such as cancer. Here, we use the engineered biological protein pore Myc...

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Bibliografiske detaljer
Main Authors: Laszlo, Andrew H., Derrington, Ian M., Brinkerhoff, Henry, Langford, Kyle W., Nova, Ian C., Samson, Jenny Mae, Bartlett, Joshua J., Pavlenok, Mikhail, Gundlach, Jens H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839702/
https://ncbi.nlm.nih.gov/pubmed/24167255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310240110
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