Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is almost always lethal. One of the underlying reasons for this lethality is believed to be the presence of cancer stem cells (CSC), which impart chemoresistance and promote recurrence, but the mechanisms responsible are unclear. Recently the poor prognosis of...

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Hlavní autoři: Asuthkar, Swapna, Stepanova, Victoria, Lebedeva, Tatiana, Holterman, AiXuan L., Estes, Norman, Cines, Douglas B., Rao, Jasti S., Gondi, Christopher S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756915/
https://ncbi.nlm.nih.gov/pubmed/23864708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-04-0306
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