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Presynaptic Neurexin-3 Alternative Splicing Trans-Synaptically Controls Postsynaptic AMPA-Receptor Trafficking

Neurexins are essential presynaptic cell-adhesion molecules that are linked to schizophrenia and autism, and are subject to extensive alternative splicing. Here, we used a novel genetic approach to test the physiological significance of neurexin alternative splicing. We generated knock-in mice in wh...

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Detalhes bibliográficos
Main Authors: Aoto, Jason, Martinelli, David C., Malenka, Robert C., Tabuchi, Katsuhiko, Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756801/
https://ncbi.nlm.nih.gov/pubmed/23827676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.060
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