Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice

The bHLH-PAS transcription factor BMAL1 (MOP3) is an essential component of the mammalian circadian pacemaker. Bmal1−/− mice lose circadian rhythmicity but also display tendon calcification and decreased activity, body weight and longevity. To investigate whether these diverse functions of BMAL1 are...

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Hauptverfasser: McDearmon, Erin L., Patel, Kush N., Ko, Caroline H., Walisser, Jacqueline A., Schook, Andrew C., Chong, Jason L., Wilsbacher, Lisa D., Song, Eun J., Hong, Hee-Kyung, Bradfield, Christopher A., Takahashi, Joseph S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756687/
https://ncbi.nlm.nih.gov/pubmed/17124323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1132430
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