Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in modu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Johnson, Brian P., Walisser, Jacqueline A., Liu, Yan, Shen, Anna L., McDearmon, Erin L., Moran, Susan M., McIntosh, Brian E., Vollrath, Aaron L., Schook, Andrew C., Takahashi, Joseph S., Bradfield, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284582/
https://ncbi.nlm.nih.gov/pubmed/25512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421708111
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