Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in modu...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Johnson, Brian P., Walisser, Jacqueline A., Liu, Yan, Shen, Anna L., McDearmon, Erin L., Moran, Susan M., McIntosh, Brian E., Vollrath, Aaron L., Schook, Andrew C., Takahashi, Joseph S., Bradfield, Christopher A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2014
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284582/
https://ncbi.nlm.nih.gov/pubmed/25512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421708111
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