Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in modu...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Johnson, Brian P., Walisser, Jacqueline A., Liu, Yan, Shen, Anna L., McDearmon, Erin L., Moran, Susan M., McIntosh, Brian E., Vollrath, Aaron L., Schook, Andrew C., Takahashi, Joseph S., Bradfield, Christopher A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284582/
https://ncbi.nlm.nih.gov/pubmed/25512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421708111
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