Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in modu...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Johnson, Brian P., Walisser, Jacqueline A., Liu, Yan, Shen, Anna L., McDearmon, Erin L., Moran, Susan M., McIntosh, Brian E., Vollrath, Aaron L., Schook, Andrew C., Takahashi, Joseph S., Bradfield, Christopher A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284582/
https://ncbi.nlm.nih.gov/pubmed/25512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421708111
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