Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in modu...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Johnson, Brian P., Walisser, Jacqueline A., Liu, Yan, Shen, Anna L., McDearmon, Erin L., Moran, Susan M., McIntosh, Brian E., Vollrath, Aaron L., Schook, Andrew C., Takahashi, Joseph S., Bradfield, Christopher A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284582/
https://ncbi.nlm.nih.gov/pubmed/25512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421708111
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