CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and function. We report that MyoD is a direct target of the circadian transcriptional activators CLOCK and BMAL1, which bind in...

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Detalles Bibliográficos
Main Authors: Andrews, Jessica L., Zhang, Xiping, McCarthy, John J., McDearmon, Erin L., Hornberger, Troy A., Russell, Brenda, Campbell, Kenneth S., Arbogast, Sandrine, Reid, Michael B., Walker, John R., Hogenesch, John B., Takahashi, Joseph S., Esser, Karyn A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973897/
https://ncbi.nlm.nih.gov/pubmed/20956306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014523107
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