CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and function. We report that MyoD is a direct target of the circadian transcriptional activators CLOCK and BMAL1, which bind in...

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Bibliografiska uppgifter
Huvudupphovsmän: Andrews, Jessica L., Zhang, Xiping, McCarthy, John J., McDearmon, Erin L., Hornberger, Troy A., Russell, Brenda, Campbell, Kenneth S., Arbogast, Sandrine, Reid, Michael B., Walker, John R., Hogenesch, John B., Takahashi, Joseph S., Esser, Karyn A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973897/
https://ncbi.nlm.nih.gov/pubmed/20956306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014523107
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