CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and function. We report that MyoD is a direct target of the circadian transcriptional activators CLOCK and BMAL1, which bind in...

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Detalhes bibliográficos
Main Authors: Andrews, Jessica L., Zhang, Xiping, McCarthy, John J., McDearmon, Erin L., Hornberger, Troy A., Russell, Brenda, Campbell, Kenneth S., Arbogast, Sandrine, Reid, Michael B., Walker, John R., Hogenesch, John B., Takahashi, Joseph S., Esser, Karyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973897/
https://ncbi.nlm.nih.gov/pubmed/20956306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014523107
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