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Role of p53 in Cell Death and Human Cancers

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indee...

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Detalhes bibliográficos
Main Authors: Ozaki, Toshinori, Nakagawara, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756401/
https://ncbi.nlm.nih.gov/pubmed/24212651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers3010994
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