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Role of p53 in Cell Death and Human Cancers
p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indee...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Molecular Diversity Preservation International (MDPI)
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756401/ https://ncbi.nlm.nih.gov/pubmed/24212651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers3010994 |
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