Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

Osteosarcoma is one of the most malignant tumors of childhood and adolescence that is often resistant to standard chemo- and radio-therapy. Geldanamycin and geldanamycin analogs have been recently studied as potential anticancer agents for osteosarcoma treatment. Here, for the first time, we have pr...

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主要な著者: Gorska, Magdalena, Marino Gammazza, Antonella, Zmijewski, Michal Aleksander, Campanella, Claudia, Cappello, Francesco, Wasiewicz, Tomasz, Kuban-Jankowska, Alicja, Daca, Agnieszka, Sielicka, Alicja, Popowska, Urszula, Knap, Narcyz, Antoniewicz, Jakub, Wakabayashi, Takashi, Wozniak, Michal
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756027/
https://ncbi.nlm.nih.gov/pubmed/24015183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071135
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