Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

Osteosarcoma is one of the most malignant tumors of childhood and adolescence that is often resistant to standard chemo- and radio-therapy. Geldanamycin and geldanamycin analogs have been recently studied as potential anticancer agents for osteosarcoma treatment. Here, for the first time, we have pr...

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Detalhes bibliográficos
Main Authors: Gorska, Magdalena, Marino Gammazza, Antonella, Zmijewski, Michal Aleksander, Campanella, Claudia, Cappello, Francesco, Wasiewicz, Tomasz, Kuban-Jankowska, Alicja, Daca, Agnieszka, Sielicka, Alicja, Popowska, Urszula, Knap, Narcyz, Antoniewicz, Jakub, Wakabayashi, Takashi, Wozniak, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756027/
https://ncbi.nlm.nih.gov/pubmed/24015183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071135
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