No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial

BACKGROUND: Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed the in vitro function of gag-protease and nef sequences...

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Autors principals: Chopera, Denis R., Mann, Jaclyn K., Mwimanzi, Philip, Omarjee, Saleha, Kuang, Xiaomei T., Ndabambi, Nonkululeko, Goodier, Sarah, Martin, Eric, Naranbhai, Vivek, Karim, Salim Abdool, Karim, Quarraisha Abdool, Brumme, Zabrina L., Ndung'u, Thumbi, Williamson, Carolyn, Brockman, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756015/
https://ncbi.nlm.nih.gov/pubmed/24015191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071758
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