No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial

BACKGROUND: Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed the in vitro function of gag-protease and nef sequences...

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Bibliografische gegevens
Hoofdauteurs: Chopera, Denis R., Mann, Jaclyn K., Mwimanzi, Philip, Omarjee, Saleha, Kuang, Xiaomei T., Ndabambi, Nonkululeko, Goodier, Sarah, Martin, Eric, Naranbhai, Vivek, Karim, Salim Abdool, Karim, Quarraisha Abdool, Brumme, Zabrina L., Ndung'u, Thumbi, Williamson, Carolyn, Brockman, Mark A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756015/
https://ncbi.nlm.nih.gov/pubmed/24015191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071758
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