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A Microfluidic Approach for Protein Structure Determination at Room Temperature via on-chip Anomalous Diffraction
We report a microfluidic approach for de novo protein structure determination via crystallization screening and optimization, as well as on-chip X-ray diffraction data collection. The structure of phosphonoacetate hydrolase (PhnA) has been solved to 2.11Å via on-chip collection of anomalous data tha...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755953/ https://ncbi.nlm.nih.gov/pubmed/23828485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3lc50276g |
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