Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted Opposite Guanidinohydantoin(,)

Continuous oxidative damage inflicted on DNA produces 7,8-dihydro-8-oxoguanine (8-oxoG), a commonly occurring lesion that can potentially cause cancer by producing G → T transversions during DNA replication. Mild oxidation of 8-oxoG leads to the formation of hydantoins, specifically guanidinohydanto...

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Main Authors: Beckman, Jeff, Wang, Mina, Blaha, Gregor, Wang, Jimin, Konigsberg, William H.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755731/
https://ncbi.nlm.nih.gov/pubmed/20795733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100913v
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