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Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP to be Inserted Opposite 7,8-Dihydroxy-8-oxoguanine

Accurate copying of the genome by DNA polymerases is challenging due in part to the continuous damage inflicted on DNA, which results from its contact with reactive oxidative species (ROS), producing lesions such as 7,8-dihydroxy-8-oxoguanine (8-oxoG). The deleterious effects of 8-oxoG can be attrib...

詳細記述

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書誌詳細
主要な著者: Beckman, Jeff, Wang, Mina, Blaha, Gregor, Wang, Jimin, Konigsberg, William H.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882254/
https://ncbi.nlm.nih.gov/pubmed/20411947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100102s
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