Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP to be Inserted Opposite 7,8-Dihydroxy-8-oxoguanine

Accurate copying of the genome by DNA polymerases is challenging due in part to the continuous damage inflicted on DNA, which results from its contact with reactive oxidative species (ROS), producing lesions such as 7,8-dihydroxy-8-oxoguanine (8-oxoG). The deleterious effects of 8-oxoG can be attrib...

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Bibliographic Details
Main Authors: Beckman, Jeff, Wang, Mina, Blaha, Gregor, Wang, Jimin, Konigsberg, William H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882254/
https://ncbi.nlm.nih.gov/pubmed/20411947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100102s
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