Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair

PURPOSE: To identify targets whose inhibition may enhance the efficacy of chemoradiation in pancreatic cancer and thus improve survival, we performed an siRNA library screen in pancreatic cancer cells. We investigated PPP2R1A, a scaffolding subunit of protein phosphatase 2A (PP2A) as a lead radiosen...

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Autori principali: Wei, Dongping, Parsels, Leslie A., Karnak, David, Davis, Mary A., Parsels, Joshua D., Zhao, Lili, Maybaum, Jonathan, Lawrence, Theodore S., Sun, Yi, Morgan, Meredith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754450/
https://ncbi.nlm.nih.gov/pubmed/23780887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0788
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