The BpeEF-OprC Efflux Pump Is Responsible for Widespread Trimethoprim Resistance in Clinical and Environmental Burkholderia pseudomallei Isolates

Trimethoprim-sulfamethoxazole (co-trimoxazole) is the primary drug used for oral eradication therapy of Burkholderia pseudomallei infections (melioidosis). Here, we demonstrate that trimethoprim resistance is widespread in clinical and environmental isolates from northeast Thailand and northern Aust...

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Autors principals: Podnecky, Nicole L., Wuthiekanun, Vanaporn, Peacock, Sharon J., Schweizer, Herbert P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754293/
https://ncbi.nlm.nih.gov/pubmed/23817379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00660-13
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